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Comparative Study
. 2003 Aug 18;13(16):2737-40.
doi: 10.1016/s0960-894x(03)00530-4.

Structure--activity relationships of azasugar-based MMP/ADAM inhibitors

Hideki Moriyama  1 , Takahiro Tsukida, Yoshimasa Inoue, Hirosato Kondo, Kohichiro Yoshino, Shin-ichiro Nishimura
Affiliations
Comparative Study

Structure--activity relationships of azasugar-based MMP/ADAM inhibitors

Hideki Moriyama et al. Bioorg Med Chem Lett. .

Abstract

In order to investigate structure-activity relationships of azasugar series toward metalloproteinases, we synthesized and evaluated several azasugar-based compounds. As a result, it was found that 4-phenoxybenzene derivative 3 having 2R,3R,4R,5S-configurations exhibited most potent inhibitory activities against matrix metalloproteinase-1, -3 and -9 and TACE.

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