Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 Jul;139(7):922-4.
doi: 10.1001/archderm.139.7.922.

Successful treatment of anogenital lichen sclerosus with topical tacrolimus

Markus Böhm  1 , Uta Frieling, Thomas A Luger, Gisela Bonsmann
Affiliations

Successful treatment of anogenital lichen sclerosus with topical tacrolimus

Markus Böhm et al. Arch Dermatol. 2003 Jul.

Abstract

Background: Lichen sclerosus of the anogenital area is a chronic inflammatory and fibrosclerotic disease associated with substantial morbidity. Topical ultrapotent corticosteroids are currently the treatment of choice.

Observations: Three prepubertal girls and 3 adults (2 men, 1 woman) were treated with 0.1% tacrolimus ointment once daily. All patients experienced complete resolution with long-lasting remission for up to 1 year. No major adverse effects were observed, and treatment was well tolerated.

Conclusions: Topical tacrolimus is a promising novel agent in the treatment of lichen sclerosus of the anogenital area. A major advantage over topical corticosteroids is the lack of skin atrophy. Further clinical trials are warranted to confirm our findings.

PubMed Disclaimer

Comment in