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Comparative Study
. 2003 Aug;71(8):4815-7.
doi: 10.1128/IAI.71.8.4815-4817.2003.

Major histocompatibility complex-dependent susceptibility to Cryptococcus neoformans in mice

Erin E McClelland  1 , Donald L Granger, Wayne K Potts
Affiliations
Comparative Study

Major histocompatibility complex-dependent susceptibility to Cryptococcus neoformans in mice

Erin E McClelland et al. Infect Immun. 2003 Aug.

Abstract

To evaluate the role of major histocompatibility complex (MHC) genes in the resistance to Cryptococcus neoformans, we conducted infection experiments in MHC-congenic strains of mice. Significant MHC-dependent susceptibility differences were found among homozygotes and heterozygotes. This study is the first experimental demonstration of MHC-dependent susceptibility to C. neoformans infections in mice and indicates that MHC genes can be important in host resistance.

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Figures

FIG. 1.
FIG. 1.
Female MHC-dependent susceptibility to C. neoformans in F2 segregants. Counts are mean numbers of CFU per whole liver ± standard errors. ⋄, median values. Sample sizes are indicated above each bar. All P values are from a Wilcoxon rank sum test. Results from all other comparisons were insignificant.
FIG. 2.
FIG. 2.
Resistance to C. neoformans in F2 segregants is inherited in both a dominant (a) and an underdominant (b) fashion. Counts are mean numbers of CFU per whole liver ± standard errors. ⋄, median values. Sample sizes are indicated above each bar. All P values are from a Wilcoxon rank sum test. Results from all other comparisons were insignificant.
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