Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2002;26(3):208-13.

Defining alcohol-related phenotypes in humans. The Collaborative Study on the Genetics of Alcoholism

Laura Jean Bierut  1 , Nancy L Saccone, John P Rice, Alison Goate, Tatiana Foroud, Howard Edenberg, Laura Almasy, P Michael Conneally, Raymond Crowe, Victor Hesselbrock, T K Li, John Nurnberger Jr, Bernice Porjesz, Marc A Schuckit, Jay Tischfield, Henri Begleiter, Theodore Reich
Affiliations
Clinical Trial

Defining alcohol-related phenotypes in humans. The Collaborative Study on the Genetics of Alcoholism

Laura Jean Bierut et al. Alcohol Res Health. 2002.

Abstract

Alcoholism is a disease that runs in families and results at least in part from genetic risk factors. The Collaborative Study on the Genetics of Alcoholism (COGA) is a Federally funded effort to identify and characterize those genetic factors. The study involves more than 1,000 alcoholic subjects and their families, with researchers conducting comprehensive psychological, physiological, electrophysiological, and genetic analyses of the participants. These analyses have identified several traits, or phenotypes, that appear to be genetically determined, such as the presence of alcohol dependence, the level of response to alcohol, the presence of coexisting depression, or the maximum number of drinks a person consumes per occasion. Genetic analyses have identified regions on several chromosomes that are associated with these phenotypes and need to be studied further.

PubMed Disclaimer

References

    1. Almasy L, Porjesz B, Blangero J, et al. Genetics of event-related brain potentials in response to a semantic priming paradigm in families with a history of alcoholism. American Journal of Human Genetics. 2001;68:128–135. - PMC - PubMed
    1. American Psychiatric Association (APA) Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised. Washington, DC: APA; 1987.
    1. American Psychiatric Association (APA) Diagnostic and Statistical Manual of Mental Disorders. Fourth Edition. Washington, DC: APA; 1994.
    1. Begleiter H, Reich T, Hesselbrock V, et al. The Collaborative Study on the Genetics of Alcoholism. Alcohol Health & Research World. 1995;19:228–236. - PMC - PubMed
    1. Bucholz KK, Cadoret R, Cloninger CR, et al. A new, semi-structured psychiatric interview for use in genetic linkage studies: A report on the reliability of the SSAGA. Journal of Studies on Alcohol. 1994;55:149–158. - PubMed

Publication types