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. 2003 Jun;26(6):449-52.
doi: 10.1007/BF02976860.

Antibacterial coumarins from Angelica gigas roots

Sanghyun Lee  1 , Dong-Sun Shin, Ju Sun Kim, Ki-Bong Oh, Sam Sik Kang
Affiliations

Antibacterial coumarins from Angelica gigas roots

Sanghyun Lee et al. Arch Pharm Res. 2003 Jun.

Abstract

Systematic fractionation of Angelica gigas roots led to the isolation of linear furano(pyrano)coumarins such as bergapten (1), decursinol angelate (2), decursin (3), nodakenetin (4) and nodakenin (5). The antibacterial activities of those compounds against pathogenic bacteria were investigated. Among the compounds tested, decursinol angelate (2) and decursin (3) exhibited significant antibacterial activity against Bacillus subtilis with the minimum inhibitory concentrations (MICs) of 50 and 12.5 microg/mL, respectively.

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