Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 Aug;5(4):209-16.
doi: 10.1016/S1098-612X(03)00007-X.

Cardiac troponin I in cats with hypertrophic cardiomyopathy

D J Connolly  1 , J Cannata, A Boswood, J Archer, E A Groves, R Neiger
Affiliations

Cardiac troponin I in cats with hypertrophic cardiomyopathy

D J Connolly et al. J Feline Med Surg. 2003 Aug.

Abstract

The molecular structure of cardiac troponin I (cTnI) is highly conserved across mammalian species and assays developed for its measurement in human patients have been validated in a number of veterinary species. A raised concentration of circulating cTnI is a sensitive and specific marker of cardiac myocyte injury. Raised levels have been documented in a variety of cardiac diseases in both human and veterinary patients. This study compared serum cTnI concentrations between 16 cats diagnosed with hypertrophic cardiomyopathy (HCM) using echocardiography and 18 control cats. The results show that cats with HCM have significantly higher concentration of serum cTnI (median 0.95 ng/ml, range 0.2-4.1 ng/ml) than control cats (median <0.2 ng/ml, range <0.2-0.25 ng/ml) [P<0.0001]. Furthermore in cats with cardiomyopathy a weak correlation was found between the thickness of the left ventricular freewall in diastole measured by ultrasound and serum cTnI concentration (r(2)=0.28;P=0.036). These results suggest that measurement of serum cTnI concentration may enable cats with cardiomyopathy to be distinguished from normal cats using the assay described here.

PubMed Disclaimer

Figures

Fig 1.
Fig 1.
Correlation with 95% CI between serum troponin and LVFWd in 16 cats with hypertrophic cardiomyopathy.
See this image and copyright information in PMC

References

    1. Adams J.E., Bodor G.S., Davila-Roman V.C., Delmez J.A., Apple F.S., Ladenson J.H., Jaffe A.S. Cardiac troponin I: A marker with high specificity for cardiac injury, Circulation, 88, 1993, 101–106. - PubMed
    1. Bertinchant J.P., Robert E., Polge A., de la Coussaye J.E., Pignodel C., Aya G., Fabbro-Peray P., Poirey S., Ledermann B., Eledjam J.J., Dauzat M. Release kinetics of cardiac troponin I and cardiac troponin T in effluents from isolated perfused rabbit hearts after graded experimental myocardial contusion, Journal of Trauma, 47, 1999, 474–480. - PubMed
    1. Briassoulis G., Papadopoulos G., Zavas N., Pailopoulos V., Hatzis T., Thanopoulos V. Cardiac troponin I in fulminant adenovirus myocarditis treated with a 24 hour infusion of high dose intravenous immunoglobulin, Pediatric Cardiology, 21, 2000, 391–394. - PubMed
    1. Colucci W.S., Braunwald E. Pathophysiology of heart failure. Braunwald E., Zipes D.P., Libby P. Heart disease: a textbook of cardiovascular medicine, 6th edn, 2001, WB Saunders: Philadelphia, 503–533.
    1. Cornelisse C.J., Schott H.C., Oliver N.B., Mullaney T.P., Koller A., Wilson D.V., Derksen F.J. Concentration of cardiac troponin I in a horse with ruptured aortic regurgitation jet lesions and ventricular tachycardia, Journal of the American Veterinary Medicine Association, 217, 2000, 231–235. - PubMed