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Clinical Trial
. 2003 Aug;47(8):2663-5.
doi: 10.1128/AAC.47.8.2663-2665.2003.

Efficacy of single-dose azithromycin in treatment of acute otitis media in children after a baseline tympanocentesis

Michael W Dunne  1 , Chandra Khurana, Adriano Arguedas Mohs, Adib Rodriguez, Antonio Arrieta, Samuel McLinn, Judy A Krogstad, Mark Blatter, Richard Schwartz, Sergio L Vargas, Paz Emparanza, Pilar Fernandez, Willis M Gooch 3rd, Mary Aspin, John Podgore, Irmeli Roine, Jeffrey L Blumer, Garth D Ehrlich, Jean Chow
Affiliations
Clinical Trial

Efficacy of single-dose azithromycin in treatment of acute otitis media in children after a baseline tympanocentesis

Michael W Dunne et al. Antimicrob Agents Chemother. 2003 Aug.

Abstract

Children with acute otitis media underwent tympanocentesis and were given a single dose of 30 mg of azithromycin/kg of body weight. At day 28, the overall clinical cure rate was 206 of 242 (85%). Clinical cure rates for patients infected with Streptococcus pneumoniae (67 of 76; 88%) and Haemophilus influenzae (28 of 44; 64%) were consistent with historical rates for the 5-day dosing regimen.

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Figures

FIG. 1.
FIG. 1.
Day 28 outcomes and MIC distributions for S. pneumoniae.
See this image and copyright information in PMC

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