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. 2003 Aug;47(8):2685-7.
doi: 10.1128/AAC.47.8.2685-2687.2003.

Thiosemicarbazole (thiacetazone-like) compound with activity against Mycobacterium avium in mice

Luiz E Bermudez  1 , Robert Reynolds, Peter Kolonoski, Pricilla Aralar, Clark B Inderlied, Lowell S Young
Affiliations

Thiosemicarbazole (thiacetazone-like) compound with activity against Mycobacterium avium in mice

Luiz E Bermudez et al. Antimicrob Agents Chemother. 2003 Aug.

Abstract

In vitro screening of thiacetazone derivatives indicated that two derivatives, SRI-286 and SRI-224, inhibited a panel of 25 Mycobacterium avium complex (MAC) isolates at concentrations of 2 micro g/ml or lower. In mice, SRI-224 and thiacetazone had no significant activity against the MAC in livers and spleens, but treatment with SRI-286 resulted in significant reduction of bacterial loads in livers and spleens. A combination of SRI-286 and moxifloxacin was significantly more active than single drug regimens in liver and spleen.

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Figures

FIG. 1.
FIG. 1.
Structures of thiacetazone, SRI-224, and SRI-286.
See this image and copyright information in PMC

References

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