Effects of norepinephrine alone and norepinephrine plus dopamine on human intestinal mucosal perfusion

Abstract

Objectives: To evaluate the effect of norepinephrine alone and norepinephrine combined with dopamine on jejunal mucosal perfusion, gastric-arterial pCO(2) gradient, and global splanchnic oxygen demand-supply relationship after cardiac surgery.

Design: A prospective interventional study.

Setting: A university cardiothoracic intensive care unit.

Patients: Eighteen patients were studied during propofol sedation and mechanical ventilation after uncomplicated coronary artery bypass surgery.

Interventions: After control measurements, each patient received norepinephrine (50+/-26 ng.kg.min) to increase mean arterial blood pressure by 30% followed by addition of low-dose dopamine (2.6+/-0.3 microg x kg x min). Postdrug control measurements were performed 120 min after discontinuation of the catecholamines.

Measurements and results: Norepinephrine induced a 32% increase in systemic vascular resistance with no change in cardiac index. Neither jejunal mucosal perfusion, assessed by laser Doppler flowmetry, nor gastric-arterial pCO(2) gradient (tonometry) was affected by norepinephrine. Splanchnic O(2)-extraction increased ( P<0.05) and this increase was positively correlated to the individual dose of norepinephrine ( r = 0.78, P<0.0001). Splanchnic lactate extraction was increased by norepinephrine ( P<0.05). None of the patients had splanchnic lactate production during norepinephrine infusion. The addition of dopamine increased cardiac index by 27% ( P<0.001) and decreased splanchnic O(2 )extraction. Dopamine increased jejunal mucosal perfusion by 32% ( P<0.001) while the gastric-arterial pCO(2) gradient remained unchanged.

Conclusions: Vasopressor therapy with norepinephrine after cardiac surgery did not jeopardize intestinal mucosal perfusion in spite of a dose-dependent increase of the global splanchnic oxygen demand-supply relationship. The addition of dopamine increased intestinal mucosal perfusion.