[Etiological and pathogenetic mechanisms in development of craniosynostoses in children]

Abstract

Craniosynostoses belong to a heterogenous group of diseases characterized by a preterm closing of cranial sutures. The symptoms may be nonsyndromal, incomplete syndromal and syndromal. Most popular are now hereditary and genetic theories of its development. The attention is focused on the factors of fibroblast growth and receptors to these factors located on osteoblasts. Gene mutation results in alteration of protein receptor structure, increased osteoblast activity and production of great amount of osteoinducing factors, collagen, acceleration of mineralization, enhancing osteogenesis in the area of cranial sutures with their preterm synostosizing (craniosynostosis).