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Case Reports
. 2003 Jul;42(7):605-8.
doi: 10.2169/internalmedicine.42.605.

Thalidomide treatment for immunoglobulin D multiple myeloma in a patient on chronic hemodialysis

Tatsuyuki Hayashi  1 , Izumi Yamaguchi, Hiroki Saitoh, Masao Takagi, Yasunobu Nonaka, Takeo Nomura
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Free article
Case Reports

Thalidomide treatment for immunoglobulin D multiple myeloma in a patient on chronic hemodialysis

Tatsuyuki Hayashi et al. Intern Med. 2003 Jul.
Free article

Abstract

A 64-year-old Japanese man suffering from IgD lambda myeloma and renal failure requiring chronic hemodialysis was treated with thalidomide. Serum IgD concentration was 4,050 mg/dl and myeloma cells constituted 95.6% of nucleated cells in bone marrow at the start of treatment. These parameters improved markedly to 1,590 mg/dl and 22.0%, respectively, in the 4 months immediately prior to his death due to pneumonia. Thalidomide caused peripheral neuropathy and constipation at a dose of 100 mg daily in the first week of treatment, but adverse effects resolved upon dose reduction. Thalidomide represents a valid therapeutic option for some myeloma patients receiving hemodialysis.

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