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Review
. 2003 Jul 18;197(1-2):81-6.
doi: 10.1016/s0304-3835(03)00086-7.

Genes co-amplified with MYCN in neuroblastoma: silent passengers or co-determinants of phenotype?

Debbie Scott  1 , Joanna Elsden, Andrew Pearson, John Lunec
Affiliations
Review

Genes co-amplified with MYCN in neuroblastoma: silent passengers or co-determinants of phenotype?

Debbie Scott et al. Cancer Lett. .

Abstract

Amplification of the MYCN oncogene in neuroblastoma is associated with poor prognosis. The amplified unit of DNA can be up to 1 Mb in size and so could contain additional genes that affect tumour phenotype. Identification of such genes may assist in optimising the determination of prognosis, and could provide new targets for treatment. Three genes have so far been identified, which are frequently co-amplified with MYCN in neuroblastoma, DDX1, NAG and N-cym. In this review, the known or putative properties of the protein products of the genes are discussed, and their possible roles in determining tumour behaviour are assessed.

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