doi: 10.1080/14734220309432.
Cerebellar ataxia associated with anti-glutamic acid decarboxylase autoantibodies
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- PMID: 12882238
- DOI: 10.1080/14734220309432
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Cerebellar ataxia associated with anti-glutamic acid decarboxylase autoantibodies
Cerebellum.
2003.
Abstract
Recent reports describe the detection of high titres of antibodies to glutamic acid decarboxylase (GAD-Ab) in the serum and cerebrospinal fluid (CSF) of patients with cerebellar ataxia. Most of these cases are females with Polyglandular Autoimmune Disorder who develop a chronic cerebellar syndrome. The CSF profile is in keeping with an autoimmune disorder and intrathecal GAD-Ab synthesis has been demonstrated. The ataxia could reverse after immunomodulatory treatments suggesting a possible pathogenetic role for GAD-Ab.
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