[Local recurrence and distant metastasis after breast-conserving therapy for patients with breast cancer]

Abstract

Objective: To study the relative factors of local recurrence and distant metastasis after breast-conserving therapy (BCT) for patients with breast cancer.

Methods: The data on 174 patients with primary breast cancer who had been treated by BCT were analyzed retrospectively. The patients were followed up for 12 to 196 months with a rate of 97.13% (169/174).

Results: Nine patients showed local recurrence and 14 patients, distant metastasis. The 3-year recurrence rate was 3.79% (5/132), the the 5-year metastasis rate was 10.99% (10/91), and the 5-year survival rate was 92.31% (84/91). Those 3-year recurrence rate for patients without radiotherapy (12.12%) was significantly higher than that with radiotherapy (1.01%), (chi(2) = 5.61, P < 0.05). In patients with node-positive, the the 5-year metastasis rate for patients without chemotherapy (44.44%) was higher than that for those with chemotherapy (6.67%), (P < 0.05). Positive marginal status was associated with local recurrence (P < 0.01). Age at diagnosis of patient with breast cancer (<or= 40 years), node-positive, and histo logical grade III were all highly significant factors of metastasis (P < 0.05).

Conclusions: Radiotherapy must be given after BCT. The patients with positive margin should be treated by re-excision or by mastectomy. Those with young age, node- positive and histological grade III should receive adjuvant chemotherapy.