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Comparative Study
. 2003 Sep;6(9):911-2.
doi: 10.1038/nn1101.

Small-conductance, Ca2+-activated K+ channel SK3 generates age-related memory and LTP deficits

Thomas Blank  1 , Ingrid Nijholt, Min-Jeong Kye, Jelena Radulovic, Joachim Spiess
Affiliations
Comparative Study

Small-conductance, Ca2+-activated K+ channel SK3 generates age-related memory and LTP deficits

Thomas Blank et al. Nat Neurosci. 2003 Sep.

Abstract

Cognitive deficits are among the most devastating changes associated with the aging process. Age-related decrement in performance on learning tasks is correlated with substantial changes in neuronal signal processing in the hippocampus. Here we show that elevated expression of small-conductance Ca2+-activated K+ channels (SK channels) of the SK3 type in hippocampi of aged mice contributes to reduced long-term potentiation (LTP) and impaired trace fear conditioning, a hippocampus-dependent learning task.

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