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. 2003 Jul 28:3:1.
doi: 10.1186/1471-2466-3-1.

Pulmonary function testing in HTLV-I and HTLV-II infected humans: a cohort study

Edward L Murphy  1 , Helen E Ownby, James W Smith, George Garratty, Sheila T Hutching, Ying Wu, Dannie I Ameti
Affiliations

Pulmonary function testing in HTLV-I and HTLV-II infected humans: a cohort study

Edward L Murphy et al. BMC Pulm Med. .

Abstract

Background: HTLV-I infection has been linked to lung pathology and HTLV-II has been associated with an increased incidence of pneumonia and acute bronchitis. However it is unknown whether HTLV-I or -II infection alters pulmonary function.

Methods: We performed pulmonary function testing on HTLV-I, HTLV-II and HTLV seronegative subjects from the HTLV outcomes study (HOST), including vital capacity (VC), forced expiratory volume in one second (FEV1), and diffusing lung capacity for carbon monoxide (DLCO) corrected for hemoglobin and lung volume. Multivariable analysis adjusted for differences in age, gender, race/ethnicity, height and smoking history.

Results: Mean (standard deviation) pulmonary function values among the 257 subjects were as follows: FVC = 3.74 (0.89) L, FEV1 = 2.93 (0.67) L, DLCOcorr = 23.82 (5.89) ml/min/mmHg, alveolar ventilation (VA) = 5.25 (1.20) L and DLCOcorr/VA = 4.54 (0.87) ml/min/mmHg/L. There were no differences in FVC, FEV1 and DLCOcorr/VA by HTLV status. For DLCOcorr, HTLV-I and HTLV-II subjects had slightly lower values than seronegatives, but neither difference was statistically significant after adjustment for confounding.

Conclusions: There was no difference in measured pulmonary function and diffusing capacity in generally healthy HTLV-I and HTLV-II subjects compared to seronegatives. These results suggest that previously described HTLV-associated abnormalities in bronchoalveolar cells and fluid may not affect pulmonary function.

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Figures

Figure 1
Figure 1
Scatter plot showing values of forced vital capacity (FVC) for each subject, with bars indicating mean, and mean plus and minus standard deviation, by HTLV status.
Figure 2
Figure 2
Scatter plot showing values of forced expiratory volume in one second (FEV1) for each subject, with bars indicating mean, and mean plus and minus standard deviation, by HTLV status.
Figure 3
Figure 3
Scatter plot showing values of diffusing capacity of carbon monoxide corrected for hemoglobin (DLCOcorr) for each subject, with bars indicating mean, and mean plus and minus standard deviation, by HTLV status.
Figure 4
Figure 4
Scatter plot showing values of diffusing capacity of carbon monoxide corrected for hemoglobin and alveolar ventilation (DLCOcorr/VA) for each subject, with bars indicating mean, and mean plus and minus standard deviation, by HTLV status.
See this image and copyright information in PMC

References

    1. Sugimoto M, Kitaichi M, Ikeda A, Nagai S, Izumi T. Chronic bronchioloalveolitis associated with human T-cell lymphotrophic virus type I infection. Curr Opin Pulm Med. 1998;4:98–102. - PubMed
    1. Matsuse T, Fukuchi Y, Hsu CY, Nagase T, Higashimoto N, Teramoto S, Matsui H, Sudo E, Kida K, Morinari H, Fukayama M, Ouchi Y, Orimo H. Detection of human T lymphotropic virus type I proviral DNA in patients with diffuse panbronchiolitis. Respirology. 1996;1:139–144. - PubMed
    1. Murphy EL, Glynn SA, Fridey J, Sacher RA, Smith JW, Wright DJ, Newman B, Gibble JW, Ameti DI, Nass CC, Schreiber GB, Nemo GJ. Increased prevalence of infectious diseases and other adverse outcomes in human T lymphotropic virus types I- and II-infected blood donors. Retrovirus Epidemiology Donor Study (REDS) Study Group. J Infect Dis. 1997;176:1468–1475. - PubMed
    1. Murphy EL, Glynn SA, Fridey J, Smith JW, Sacher RA, Nass CC, Ownby HE, Wright DJ, Nemo GJ. Increased incidence of infectious diseases during prospective follow-up of human T-lymphotropic virus type II- and I-infected blood donors. Retrovirus Epidemiology Donor Study. Arch Intern Med. 1999;159:1485–1491. doi: 10.1001/archinte.159.13.1485. - DOI - PubMed
    1. Mukae H, Kohno S, Morikawa N, Kadota J, Matsukura S, Hara K. Increase in T-cells bearing CD25 in bronchoalveolar lavage fluid from HAM/TSP patients and HTLV-I carriers. Microbiol Immunol. 1994;38:55–62. - PubMed

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