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Review
. 2003 Jun;13(2):79-92.
doi: 10.1023/a:1023832305702.

Alzheimer's disease as a disconnection syndrome?

X Delbeuck  1 , M Van der Linden, F Collette
Affiliations
Review

Alzheimer's disease as a disconnection syndrome?

X Delbeuck et al. Neuropsychol Rev. 2003 Jun.

Abstract

This paper reviews the growing amount of evidence supporting the hypothesis that Alzheimer's disease includes a disconnection syndrome. This evidence came mainly from neuropathological, electrophysiological, and neuroimaging studies. Moreover, a few recent neuropsychological studies have also explored the effects of a disconnection between cerebral areas on cognitive functioning. Finally, and more generally, the contribution of this interpretation to the understanding of Alzheimer's disease cognitive deficits is considered.

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