[Noninvasive monitoring of hypertensive intracerebral hemorrhage and perihematomal tissue edema]

Abstract

Objective: To investigate the dynamic change regularity of intracerebral hemorrhage and perihematomal tissue edema.

Methods: The cerebral electric impedance (CEI) of 100 normal volunteers and 24 patients with hypertensive intracerebral hemorrhage was measured, and the results of measurement were compared with the volumes of hematoma detected by CT.

Results: In the normal persons, the CEI values in the left and right sides of cerebral hemispheres were 11.5 +/- 1.3 k(Omega) vs 11.4 +/- 1.8 k(Omega) at the frequency of 20 kHz, 10.2 +/- 1.0 k(Omega) vs 10.3 +/- 1.1 k(Omega) at the frequency of 50 kHz, and 9.1 +/- 0.8 k(Omega) vs 9.2 +/- 0.8 k(Omega) at the frequency of 100 kHz (all P > 0.05). Age, sex and measuring time did not obviously affect the CEI values. In the patients with hypertensive intracerebral hemorrhage the CEI of hematoma side was significantly decreased within 2 days after onset and then increased significantly for more than 10 days. The rate of EI change in the hematoma side within 24 h had a negative correlation with the volume of hematoma (r = -0.895 3, P < 0.01). however, the rate of CEI change in the hematoma side had a positive correlation with the volume of perihematomal edema (r = 0.881 1, P < 0.01).

Conclusion: CEI is a stable physical parameter reflecting the electrical character of human brain tissue. CEI sensitively reflects the change of hematoma and perihematomal edema, and guides the clinical treatment of cerebral hemorrhage.