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Review
. 2003 Jul;12(1):1-3.
doi: 10.1016/s1097-2765(03)00284-3.

Inactivating chromosomes: a macro domain that minimizes transcription

Andreas G Ladurner  1
Affiliations
Free article
Review

Inactivating chromosomes: a macro domain that minimizes transcription

Andreas G Ladurner. Mol Cell. 2003 Jul.
Free article

Abstract

The histone variant macroH2A plays a role in mammalian chromosome X inactivation. Recent data suggest its unusual C-terminal macro domain may be an enzyme that regulates the ADP-ribosylation of chromatin. MacroH2A could thus help correct gene dosage between males and females using a novel epigenetic mark.

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