Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 Jul;12(1):87-100.
doi: 10.1016/s1097-2765(03)00244-2.

The CCT chaperonin promotes activation of the anaphase-promoting complex through the generation of functional Cdc20

Alain Camasses  1 , Aliona Bogdanova, Andrej Shevchenko, Wolfgang Zachariae
Affiliations
Free article

The CCT chaperonin promotes activation of the anaphase-promoting complex through the generation of functional Cdc20

Alain Camasses et al. Mol Cell. 2003 Jul.
Free article

Abstract

The WD repeat protein Cdc20 is essential for progression through mitosis because it is required to activate ubiquitin ligation by the anaphase-promoting complex (APC/C). Here we show in yeast that Cdc20 binds to the CCT chaperonin, which is known as a folding machine for actin and tubulin. The CCT is required for Cdc20's ability to bind and activate the APC/C. In vivo, CCT is essential for Cdc20-dependent cell cycle events such as sister chromatid separation and exit from mitosis. The chaperonin is also required for the function of the Cdc20-related protein Cdh1, which activates the APC/C during G1. We propose that folding of the Cdc20 family of APC/C activators is an essential and evolutionary conserved function of the CCT chaperonin.

PubMed Disclaimer

Publication types

MeSH terms