Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2003 Aug 8;331(2):303-13.
doi: 10.1016/s0022-2836(03)00721-6.

Chemical cross-linking and mass spectrometry for protein structural modeling

Jaap Willem Back  1 , Luitzen de Jong, Anton O Muijsers, Chris G de Koster
Affiliations
Review

Chemical cross-linking and mass spectrometry for protein structural modeling

Jaap Willem Back et al. J Mol Biol. .

Abstract

The growth of gene and protein sequence information is currently so rapid that three-dimensional structural information is lacking for the overwhelming majority of known proteins. In this review, efforts towards rapid and sensitive methods for protein structural characterization are described, complementing existing technologies. Based on chemical cross-linking and offering the analytical speed and sensitivity of mass spectrometry these methodologies are thought to contribute valuable tools towards future high throughput protein structure elucidation.

PubMed Disclaimer

LinkOut - more resources