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. 1992 Sep;105(9):732-7.

Effects of atrial natriuretic factor on patients with renovascular hypertension

W G Zhang  1 , L S Liu, D Y Zheng, G Z Liu, L Jin, X W Zhao, B Ren
Affiliations
  • PMID: 1288975

Effects of atrial natriuretic factor on patients with renovascular hypertension

W G Zhang et al. Chin Med J (Engl). 1992 Sep.

Abstract

Previous studies have shown the effects of atrial natriuretic factor (ANF) on rats with renovascular hypertension (RVH). In the present study low dose alpha-hANF (0.025 microgram/kg/min) was administered intravenously for 60 minutes to seven RVH patients. Results demonstrated an inhibition of renin-angiotensin-aldosterone system (RAAS), reduction of plasma catecholamine and arginine vasopressin(AVP), diuresis and natriuresis, increase of hematocrit and creatinine clearance, and slight decrease of blood pressure. These results showed that most factors involved in the establishment and maintenance of RVH are affected by ANF infusion.

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