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Comparative Study
. 2003 Aug;139(7):1249-53.
doi: 10.1038/sj.bjp.0705368.

Acute effects of oestrogen receptor subtype-specific agonists on vascular contractility

Sandra Montgomery  1 , Linda Shaw, Nick Pantelides, Michael Taggart, Clare Austin
Affiliations
Comparative Study

Acute effects of oestrogen receptor subtype-specific agonists on vascular contractility

Sandra Montgomery et al. Br J Pharmacol. 2003 Aug.

Abstract

This study shows for the first time that both the putatively selective oestrogen receptor alpha and oestrogen receptor beta agonists PPT (4,4',4"-(4-propyl-[(1)H]-pyrazole-1,3,5-triyl) tris-phenol) and DPN (2,3-bis(4-hydroxyphenyl)-propionitrile) can acutely relax precontracted isolated rat mesenteric arteries at pharmacological (i.e. micro M) concentrations. When compared to responses observed to similar concentrations of 17beta-oestrogen obtained on the same tissues, PPT had a significantly greater vasodilatory effect, while DPN had a significantly smaller effect. All responses were rapid being complete within 5 min exposure time. Thus, both PPT and DPN can acutely relax isolated mesenteric arteries with the relative potency of PPT>17beta-oestrogen>DPN.

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Figures

Figure 1
Figure 1
A comparison of the effects of 17β-oestradiol and (a) PPT and (b) DPN on the contractility of isolated rat mesenteric arteries precontracted with KPSS alone. **P<0.005.
See this image and copyright information in PMC

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