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. 2003 Aug 1;301(5633):649-53.
doi: 10.1126/science.1082690.

Reelin promotes peripheral synapse elimination and maturation

Carlo C Quattrocchi  1 , Cheng Huang, Sanyong Niu, Michael Sheldon, David Benhayon, Joiner Cartwright Jr, Dennis R Mosier, Flavio Keller, Gabriella D'Arcangelo
Affiliations

Reelin promotes peripheral synapse elimination and maturation

Carlo C Quattrocchi et al. Science. .

Erratum in

  • Science. 2003 Sep;301(5641):1849

Retraction in

  • Retraction.
    Quattrocchi CC, Huang C, Niu S, Sheldon M, Benhayon D, Cartwright J Jr, Mosier DR, Keller F, D'Arcangelo G. Quattrocchi CC, et al. Science. 2004 Mar 26;303(5666):1974. doi: 10.1126/science.303.5666.1974b. Science. 2004. PMID: 15044784 No abstract available.

Abstract

Reelin is an extracellular protein that is crucial for layer formation in the embryonic brain. Here, we demonstrate that Reelin functions postnatally to regulate the development of the neuromuscular junction. Reelin is required for motor end-plate maturation and proper nerve-muscle connectivity, and it directly promotes synapse elimination. Unlike layer formation, neuromuscular junction development requires a function of Reelin that is not mediated by Disabled1 or very-low-density lipoprotein receptors and apolipoprotein E receptor 2 receptors but by a distinct mechanism involving its protease activity.

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