Review
doi: 10.1586/14760584.1.3.293.
Conditional live virus as a novel approach towards a safe live attenuated HIV vaccine
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- PMID: 12901570
- DOI: 10.1586/14760584.1.3.293
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Review
Conditional live virus as a novel approach towards a safe live attenuated HIV vaccine
Expert Rev Vaccines.
2002 Oct.
Abstract
To control the worldwide spread of HIV, a safe and effective prophylactic vaccine is urgently needed. Studies with the simian immunodeficiency virus demonstrated that a live attenuated virus can be effective as a vaccine, but serious concerns about the safety of such a vaccine virus have arisen. We propose a conditional live virus, of which the replication can be switched on and off at will, as a novel approach for an HIV vaccine.
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