[Ototoxicity of gentamicin assessed by the vestibular evoked potentials]

Abstract

Objective: To assess ototoxicity of gentamicin by the vestibular evoked potentials (VsEPs) and auditory brainstem response (ABR).

Methods: 40 guinea pigs were divided randomly into 4 groups, 10 animals of group A were injected gentamicin intramuscularly 60 mg/(kg.d). 10 of group B were injected Ns intramuscularly 0.5 ml/d as control. 10 of group C were given gentamicin intratympanic 5 mg/d(0.1 ml). 10 of group D were given Ns intratympanic 0.1 ml/d as control. ABR and VsEPs were measured prior to and following the administration.

Results: After treatment group A 21 days, 40 days, group C 5 days, 10 days, ABR and VsEPs showed significant changes, corresponding to histopathological examination of the temporal bones.

Conclusion: VsEPs used in assessing ototoxicity of gentamicin just as ABR.