doi: 10.1021/ja035001g.
Toward a versatile allylation reagent: practical, enantioselective allylation of acylhydrazones using strained silacycles
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- PMID: 12904019
- DOI: 10.1021/ja035001g
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Toward a versatile allylation reagent: practical, enantioselective allylation of acylhydrazones using strained silacycles
J Am Chem Soc.
.
Abstract
A highly practical method for the enantioselective allylation of acylhydrazones has been developed. The previously reported strained silacycle reagent 1 reacts with a wide variety of acylhydrazones to give the hydrazide products with good enantioselectivity (83-89% ee, typically). It has been demonstrated that the products may be isolated without chromatography by recrystallization in >/=98% ee.
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