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. 2003 Aug 13;125(32):9596-7.
doi: 10.1021/ja035001g.

Toward a versatile allylation reagent: practical, enantioselective allylation of acylhydrazones using strained silacycles

Richard Berger  1 , Philippe M A Rabbat, James L Leighton
Affiliations

Toward a versatile allylation reagent: practical, enantioselective allylation of acylhydrazones using strained silacycles

Richard Berger et al. J Am Chem Soc. .

Abstract

A highly practical method for the enantioselective allylation of acylhydrazones has been developed. The previously reported strained silacycle reagent 1 reacts with a wide variety of acylhydrazones to give the hydrazide products with good enantioselectivity (83-89% ee, typically). It has been demonstrated that the products may be isolated without chromatography by recrystallization in >/=98% ee.

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