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. 2001 Oct;23(5):499-501.

[Relationship between alpha-ENaC gene Thr663Ala polymorphism and ischemic stroke]

[Article in Chinese]
Y Zhao  1 , L Y Ma, Y X Liu, X Y Wang, L S Liu, K Lindpaintner
Affiliations
  • PMID: 12905871

[Relationship between alpha-ENaC gene Thr663Ala polymorphism and ischemic stroke]

[Article in Chinese]
Y Zhao et al. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2001 Oct.

Abstract

Objective: To determine the relationship between Thr663Ala polymorphism in amiloride-sensitive epithelial sodium channel alpha-subunit (alpha-ENaC) gene and ischemic stroke in Chinese population.

Methods: Two hundred and ninety-four patients with cerebral infarction and 280 controls without stroke were screened by polymerase chain reaction (PCR) and corresponding Thr663Ala polymorphism probe hybridization.

Results: Thr663Ala polymorphism was in agreement with Hardy-Weinberg equilibrium. Both the carriers proportion (70.75%) and the frequency (48.64%) of 663Ala allele in patients were more prevalent than that in controls (62.86% and 40.89%) (P < 0.05). The presence of at least one 663Ala allele conferred an odds ratio for stroke of 1.429 (95%CI: 1.009-2.025), and the proportion of attributable risk of population (PAR%) was 11.63%.

Conclusion: Thr 663Ala polymorphism of alpha-ENaC gene may be a genetic risk of ischemic stroke in Chinese population.

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