Receptor-ligand binding: 'catch' bonds finally caught
- PMID: 12906816
- DOI: 10.1016/s0960-9822(03)00529-3
Receptor-ligand binding: 'catch' bonds finally caught
Abstract
Leukocyte recruitment to sites of inflammation is initiated by the selectin family of adhesion receptors. Recent research reveals that P-selectin binding to its ligand exhibits 'catch' to 'slip' bond transition that may help explain the shear threshold phenomenon.
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