Shikimate dehydrogenase structure reveals novel fold
- PMID: 12906820
- DOI: 10.1016/s0969-2126(03)00165-5
Shikimate dehydrogenase structure reveals novel fold
Abstract
The structure of shikimate 5-dehydrogenase, the fourth enzyme in the shikimate biosynthesis pathway and a member of a large enzyme family without clear structural peer, reveals a novel topological fold for the substrate binding domain and, through homology modeling, expands the possibilities for antimicrobial and herbicide design.
Comment on
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Crystal structure of shikimate 5-dehydrogenase (SDH) bound to NADP: insights into function and evolution.Structure. 2003 Aug;11(8):1005-13. doi: 10.1016/s0969-2126(03)00159-x. Structure. 2003. PMID: 12906831
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