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. 2003 Aug;124(2):740-3.
doi: 10.1378/chest.124.2.740.

Statins, inflammation, and sepsis: hypothesis

Yaniv Almog  1
Affiliations

Statins, inflammation, and sepsis: hypothesis

Yaniv Almog. Chest. 2003 Aug.

Abstract

Sepsis and septic shock are complex inflammatory syndromes. Multiple cellular activation processes are involved, and many humoral cascades are triggered. Statins have anti-inflammatory properties. Our preliminary observations indicate that patients receiving therapy with statins may have a lower incidence of severe sepsis. We hypothesize that statins have a strong protective effect against sepsis by virtue of diverse anti-inflammatory effects that are independent of their lipid-lowering ability.

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Comment in

  • Statin, inflammation, and sepsis.
    Inoue K, Takano H, Yanagisawa R, Sakurai M, Yoshikawa T. Inoue K, et al. Chest. 2004 Jun;125(6):2365; author reply 2365. doi: 10.1378/chest.125.6.2365. Chest. 2004. PMID: 15189966 No abstract available.

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