doi: 10.1378/chest.124.2.740.
Statins, inflammation, and sepsis: hypothesis
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- PMID: 12907568
- DOI: 10.1378/chest.124.2.740
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Statins, inflammation, and sepsis: hypothesis
Chest.
2003 Aug.
Abstract
Sepsis and septic shock are complex inflammatory syndromes. Multiple cellular activation processes are involved, and many humoral cascades are triggered. Statins have anti-inflammatory properties. Our preliminary observations indicate that patients receiving therapy with statins may have a lower incidence of severe sepsis. We hypothesize that statins have a strong protective effect against sepsis by virtue of diverse anti-inflammatory effects that are independent of their lipid-lowering ability.
Comment in
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Statin, inflammation, and sepsis.Chest. 2004 Jun;125(6):2365; author reply 2365. doi: 10.1378/chest.125.6.2365. Chest. 2004. PMID: 15189966 No abstract available.
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