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. 2003 Aug;59(Pt 8):o428-30.
doi: 10.1107/s0108270103012514. Epub 2003 Jul 12.

Simvastatin

Jan Cejka  1 , Bohumil Kratochvíl, Ivana Císarová, Alexandr Jegorov
Affiliations

Simvastatin

Jan Cejka et al. Acta Crystallogr C. 2003 Aug.

Abstract

Simvastatin, or (1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-3,4,5,6-tetrahydro-2H-pyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate, C(25)H(38)O(5), is almost isostructural with lovastatin, and the general conformational features are closely related to those of other reported crystal structures of statins. The only hydrogen bond present facilitates the formation of infinite chains of molecules along the b axis.

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