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Comment
. 2003 Aug 19;100(17):9650-2.
doi: 10.1073/pnas.1934245100. Epub 2003 Aug 11.

tRNA synthetase paralogs: evolutionary links in the transition from tRNA-dependent amino acid biosynthesis to de novo biosynthesis

Christopher Francklyn  1
Affiliations
Comment

tRNA synthetase paralogs: evolutionary links in the transition from tRNA-dependent amino acid biosynthesis to de novo biosynthesis

Christopher Francklyn. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
A model of the temporal order in which amino acids emerged, emphasizing the relationship between direct and indirect pathways. The amino acids are arranged in three groups, which reflect their order of emergence (21). The dotted line among the early amino acids highlights the possibility that some of the smaller, simpler amino acids might have always been synthesized by using direct routes. The double line demarcates the transition from the RNA world to protein world, and the downward arrow signifies emergence of indirect pathways. HisZ and AsnA, the putative evolutionary links between direct and indirect pathways, are highlighted above arrows showing the direction of evolution from indirect to direct pathways.
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