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Comparative Study
. 2003 Aug 19;100(17):9653-5.
doi: 10.1073/pnas.1834191100. Epub 2003 Aug 11.

Neurodegenerative tauopathy in the worm

Michel Goedert  1
Affiliations
Comparative Study

Neurodegenerative tauopathy in the worm

Michel Goedert. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
Mutations in Tau in FTDP-17. (a) Schematic diagram of the six tau isoforms (352–441 aa) expressed in adult human brain, with mutations in the coding region indicated by using the numbering of the 441-aa isoform. The six isoforms are produced by alternative mRNA splicing from a single gene and differ by the presence or absence of three inserts, shown in red (encoded by exon 2), green (encoded by exon 3), and yellow (encoded by exon 10). Exon 2 codes for the 29-aa insert, exons 2 and 3 code for the 58-aa insert, and exon 10 codes for the 31-aa repeat. Nineteen missense mutations, two deletion mutations, and three silent mutations are shown. Kraemer et al. (5) produced lines of C. elegans transgenic for the 412-aa isoform (arrow) without and with mutations P301L or V337M (indicated in red). (b) Predicted stem-loop structure in the pre-mRNA at the boundary between exon 10 and the intron that follows it, with nine mutations that destabilize the stem loop. Exon sequences are boxed and shown in uppercase letters, and intron sequences are shown in lowercase letters.
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Comment on

References

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