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. 2003 Jun 18;35(3):241-7.

Inhibition by peripheral electric stimulation of the reinstatement of morphine-induced place preference in rats and drug-craving in heroin addicts

Bin Wang  1 , Benguo Zhang, Xuecai Ge, Fei Luo, Jisheng Han
Affiliations
  • PMID: 12914237
Free article

Inhibition by peripheral electric stimulation of the reinstatement of morphine-induced place preference in rats and drug-craving in heroin addicts

Bin Wang et al. Beijing Da Xue Xue Bao Yi Xue Ban. .
Free article

Abstract

Objective: To test the hypothesis that peripheral electric stimulation (PES) may suppress the reinstatement of morphine-induced conditioned place preference (CPP) in rats as well as the drug craving of detoxified heroin addicts in a frequency-dependent manner.

Methods: CPP model of the rat was constructed with two compartment automatic CPP apparatus, and the craving of the heroin addicts was assessed with a visual analogue scale (VAS).

Results: (1) PES of low frequency could prevent the drug priming- or foot shock-induced reinstatement of morphine CPP; (2) this effect was naloxone-reversible, suggesting a possible involvement of endogenous opioid mechanisms; and (3) PES of low frequency could also accelerate the rate of natural decay of drug craving in heroin addicts after successful abstinence.

Conclusion: PES might serve as a therapeutic measure for the treatment of heroin addiction.

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