Comment on

• CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members.

  Trompouki E, Hatzivassiliou E, Tsichritzis T, Farmer H, Ashworth A, Mosialos G. Trompouki E, et al. Nature. 2003 Aug 14;424(6950):793-6. doi: 10.1038/nature01803. Nature. 2003. PMID: 12917689
• Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB.

  Brummelkamp TR, Nijman SM, Dirac AM, Bernards R. Brummelkamp TR, et al. Nature. 2003 Aug 14;424(6950):797-801. doi: 10.1038/nature01811. Nature. 2003. PMID: 12917690
• The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination.

  Kovalenko A, Chable-Bessia C, Cantarella G, Israël A, Wallach D, Courtois G. Kovalenko A, et al. Nature. 2003 Aug 14;424(6950):801-5. doi: 10.1038/nature01802. Nature. 2003. PMID: 12917691