An improved procedure for the synthesis of benzimidazoles, using palladium-catalyzed aryl-amination chemistry

Abstract

New, improved conditions have been developed and optimized for the synthesis of benzimidazoles by intramolecular palladium-catalyzed aryl-amination chemistry. This methodology, combined with a "catch and release" purification strategy, has led to a range of these heterocycles being prepared rapidly and in excellent yield.