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Review
. 2003 Nov 1;23(11):1979-89.
doi: 10.1161/01.ATV.0000091250.53231.4D. Epub 2003 Aug 14.

Intramural plasminogen activator inhibitor type-1 and coronary atherosclerosis

Burton E Sobel  1 , Douglas J Taatjes, David J Schneider
Affiliations
Review

Intramural plasminogen activator inhibitor type-1 and coronary atherosclerosis

Burton E Sobel et al. Arterioscler Thromb Vasc Biol. .

Abstract

Altered expression of plasminogen activator inhibitor type-1 in vessel walls, reviewed here, might affect coronary atherogenesis. Upregulation might exacerbate vasculopathy by potentiating thrombosis and by inhibiting vascular smooth muscle cell migration, resulting in attenuation of thickness of elaborated fibrous caps implicated in the vulnerability of atheroma to rupture.

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