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Review
. 2003 Nov;52(11):670-9.
doi: 10.1007/s00262-003-0425-4. Epub 2003 Aug 15.

Tumor microvasculature as a barrier to antitumor immunity

Qing Chen  1 , Wan-Chao Wang, Sharon S Evans
Affiliations
Review

Tumor microvasculature as a barrier to antitumor immunity

Qing Chen et al. Cancer Immunol Immunother. 2003 Nov.
No abstract available

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Figures

Fig. 1A–F.
Fig. 1A–F.
Immunohistochemical staining of human primary lung carcinoma (A, B), breast carcinoma (C, D), or malignant melanoma (E, F), showing peritumoral localization (left panels) or intratumoral infiltration (right panels) by CD45+ leukocytes. Arrows indicate CD45+ immune cells; T indicates tumor parenchymal cells. (Photomicrographs courtesy of Dr. Bonnie Hylander and Dr. Elizabeth Repasky, Dept. of Immunology, Roswell Park Cancer Institute, Buffalo, NY)
Fig. 2.
Fig. 2.
Paradigm for step-wise adhesive interactions that lead to lymphocyte extravasation across postcapillary high endothelial venules (HEVs)
Fig. 3A, B.
Fig. 3A, B.
Fever-range thermal stress stimulates intratumoral infiltration of leukocytes in murine colon 26 tumors (A) and promotes lymphocyte adhesion to HEV in lymph node cryosections (B). A Mice were exposed to fever-range whole body hyperthermia (39.5–40°C for 6 h) and tumor tissues were stained with H&E to visualize infiltrating lymphocytes (black arrows) or neutrophils (white arrows). (Photomicrographs were kindly provided by Dr. Julie Ostberg and Dr. Elizabeth Repasky). B Human peripheral blood lymphocytes (PBLs) were cultured at 37°C or 40°C for 6 h. Adhesion of toluidine-stained human PBL (darkly stained cells indicated by arrows) to individual HEV of murine lymph node tissue cryosections was assessed under mechanical shear. Adhesion was also quantified in the presence of function-blocking monoclonal antibodies specific for L-selectin (DREG-56) and PNAd (MECA-79). Data are the mean ± standard error of triplicate samples; brackets indicate the net level of L-selectin or PNAd-specific adhesion. The differences between adhesion of PBL under normothermal control conditions and hyperthermic treatments were determined to be significant, * p<0.0001, using an unpaired two-tailed Student's t-test
See this image and copyright information in PMC

References

    1. Armstrong Surg Oncol Clin N Am. 2002;11:681. - PubMed
    1. Davis ID, Jefford M, Parente P, Cebon J. Rational approaches to human cancer immunotherapy. J Leukoc Biol. 2003;73:3–29. - PubMed
    1. Mocellin Cancer Immunol Immunother. 2002;51:583. doi: 10.1007/s00262-002-0308-0. - DOI - PMC - PubMed
    1. Johnson Lung Cancer. 2000;27:27. doi: 10.1016/S0169-5002(99)00095-1. - DOI - PubMed
    1. Lee Cancer. 1989;63:309. - PubMed

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