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Clinical Trial
. 2003 Sep;18(9):1918-21.
doi: 10.1093/humrep/deg368.

Effectiveness of auto-cross-linked hyaluronic acid gel in the prevention of intrauterine adhesions after hysteroscopic adhesiolysis: a prospective, randomized, controlled study

Giuseppe Acunzo  1 , Maurizio Guida, Massimiliano Pellicano, Giovanni Antonio Tommaselli, Attilio Di Spiezio Sardo, Giuseppe Bifulco, Domenico Cirillo, Alex Taylor, Carmine Nappi
Affiliations
Clinical Trial

Effectiveness of auto-cross-linked hyaluronic acid gel in the prevention of intrauterine adhesions after hysteroscopic adhesiolysis: a prospective, randomized, controlled study

Giuseppe Acunzo et al. Hum Reprod. 2003 Sep.

Abstract

Background: A prospective, randomized, controlled study was performed to assess the efficacy of auto-cross-linked hyaluronic acid (ACP) gel in preventing the development of intrauterine adhesions following hysteroscopic adhesiolysis.

Methods: Ninety-two patients with irregular menses and intrauterine adhesions referred to the Hysteroscopic Unit of the University of Naples "Federico II". Patients were randomized to two different groups. Group A were randomized to hysteroscopic adhesiolysis plus intrauterine application of ACP gel (10 ml) and group B were randomized to operative hysteroscopy alone (control group). Baseline adhesion scores were calculated for each patient and at 3 months after surgery.

Results: Group A showed a significant decrease in intrauterine adhesions at 3 months follow-up in comparison with the control group. Staging of adhesions showed a significant decrease in adhesion severity in patients treated with ACP gel.

Conclusions: ACP gel significantly reduces the development of intrauterine adhesions postoperatively and its use is likely to be associated with a reduction of severe adhesions.

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