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Review
. 2003 Aug;34(4):369-76.
doi: 10.1038/ng1215.

Chromosome aberrations in solid tumors

Donna G Albertson  1 , Colin Collins, Frank McCormick, Joe W Gray
Affiliations
Review

Chromosome aberrations in solid tumors

Donna G Albertson et al. Nat Genet. 2003 Aug.

Abstract

Chromosome aberrations in human solid tumors are hallmarks of gene deregulation and genome instability. This review summarizes current knowledge regarding aberrations, discusses their functional importance, suggests mechanisms by which aberrations may form during cancer progression and provides examples of clinical advances that have come from studies of chromosome aberrations.

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