Review
doi: 10.1046/j.1526-0968.2003.00051.x.
Heparin-induced extracorporeal low-density lipoprotein precipitation
Affiliations
- PMID: 12924614
- DOI: 10.1046/j.1526-0968.2003.00051.x
Item in Clipboard
Review
Heparin-induced extracorporeal low-density lipoprotein precipitation
Ther Apher Dial.
2003 Jun.
Abstract
Heparin-induced extracorporeal low-density lipoprotein (LDL) precipitation (HELP) is a selective and careful apheresis procedure. Through the application of heparin and lowering the pH value, lipoproteins and fibrinogen are reduced by 50-60%. In addition, adhesion molecules (ICAM-1, VCAM-1, p-selectin) which play a key role in the development and progression of atherosclerosis, are also markedly reduced. A PET scan performed 20 h after LDL apheresis shows the improvement of coronary vasodilation capacity. This is supposed to be mainly due to the marked reduction of LDL cholesterol and fibrinogen with consecutive improvement of endothelial dysfunction and rheology.
Similar articles
-
[Heparin-induced extracorporeal LDL precipitation (H.E.L.P.)].Z Kardiol. 2003;92(Suppl 3):III1-5. doi: 10.1007/s00392-003-1304-x. Z Kardiol. 2003. PMID: 14663596 Review. German.
-
Extracorporal low-density lipoprotein elimination by immunoadsorption.Ther Apher Dial. 2003 Jun;7(3):370-2. doi: 10.1046/j.1526-0968.2003.00054.x. Ther Apher Dial. 2003. PMID: 12924615 Review.
-
[Myocardial perfusion under H.E.L.P. -apheresis. Objectification by PET].Z Kardiol. 2003;92(Suppl 3):III30-7. doi: 10.1007/s00392-003-1303-y. Z Kardiol. 2003. PMID: 14663599 Clinical Trial. German.
-
Indication of low-density lipoprotein apheresis in severe hypercholesterolemia and its atherosclerotic vascular complications: dextran sulfate cellulose low-density lipoprotein apheresis.Ther Apher Dial. 2003 Jun;7(3):345-9. doi: 10.1046/j.1526-0968.2003.00063.x. Ther Apher Dial. 2003. PMID: 12924611 Review.
-
From membrane differential filtration to lipidfiltration: technological progress in low-density lipoprotein apheresis.Ther Apher Dial. 2003 Jun;7(3):350-8. doi: 10.1046/j.1526-0968.2003.00062.x. Ther Apher Dial. 2003. PMID: 12924612 Review.
Cited by
-
HELP apheresis in hypercholesterolemia and cardiovascular disease: efficacy and adverse events after 8,500 procedures.Clin Res Cardiol Suppl. 2012 Jun;7(Suppl 1):24-30. doi: 10.1007/s11789-012-0048-4. Clin Res Cardiol Suppl. 2012. PMID: 22528135 Free PMC article.
-
Low-density lipoprotein apheresis: an evidence-based analysis.Ont Health Technol Assess Ser. 2007;7(5):1-101. Epub 2006 Nov 1. Ont Health Technol Assess Ser. 2007. PMID: 23074505 Free PMC article.
-
Update on Clinical Trials in Dry Age-related Macular Degeneration.Middle East Afr J Ophthalmol. 2016 Jan-Mar;23(1):13-26. doi: 10.4103/0974-9233.173134. Middle East Afr J Ophthalmol. 2016. PMID: 26957835 Free PMC article. Review.
-
Lipoprotein glomerulopathy treated with LDL-apheresis (Heparin-induced Extracorporeal Lipoprotein Precipitation system): a case report.J Med Case Rep. 2009 Dec 2;3:9311. doi: 10.1186/1752-1947-3-9311. J Med Case Rep. 2009. PMID: 20062740 Free PMC article.
-
Pathogenesis, histopathologic findings and treatment modalities of lipoprotein glomerulopathy: A review.J Bras Nefrol. 2019 Jul-Sep;41(3):393-399. doi: 10.1590/2175-8239-jbn-2018-0148. Epub 2018 Nov 8. J Bras Nefrol. 2019. PMID: 30421781 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous
