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. 2003 Jul-Aug;23(4):3151-7.

Expression of cytokines and receptors in normal, immortalized, and malignant ovarian epithelial cell lines

Christina A Bandera  1 , Hing Wo Tsui, Samuel C Mok, Florence W Tsui
Affiliations
  • PMID: 12926048

Expression of cytokines and receptors in normal, immortalized, and malignant ovarian epithelial cell lines

Christina A Bandera et al. Anticancer Res. 2003 Jul-Aug.

Abstract

Background: Ovarian carcinoma originates from the epithelial cells on the surface of the ovary. This study evaluates cytokine production by these cells.

Materials and methods: Normal human ovary surface epithelial cells (HOSE cells), immortalized HOSE cells and ovarian cancer cells were used for the study of cytokines.

Results: Eight of 14 cytokines were increased in > or = 3 ovarian cancer cell lines compared with normal HOSE cells. Three cytokines were increased 5-fold in the immortalized HOSE cell line and in multiple ovarian cancer cell lines. Cytokine receptor expression revealed that 7 of 8 ovarian cancer cell lines had > or = 1 autocrine loop. Anti-EGFR antibody failed to inhibit growth of ovarian cancer cells which expressed multiple cytokine receptors.

Conclusion: Ovarian cancer cells produce more cytokines than normal HOSE cells. Immortalized HOSE cells display a cytokine profile similar to the cancer cells. Finally, multiple autocrine loops in ovarian cancer may limit the therapeutic usefulness of single cytokine receptor blockade.

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