Review
doi: 10.1093/hmg/ddg286.
Epub 2003 Aug 19.
DNA methylation and Rett syndrome
Affiliations
- PMID: 12928486
- DOI: 10.1093/hmg/ddg286
Item in Clipboard
Review
DNA methylation and Rett syndrome
Hum Mol Genet.
.
Abstract
Methylation of cytosine in human DNA has been studied for over 60 years, but has only recently been confirmed as an important player in human disease. Rett syndrome is a neurological disorder caused by mutations in the MeCP2 protein, which has been shown to bind methylated DNA and repress transcription. This review will focus on experiments addressing the basic properties of MeCP2 and on mouse models of Rett syndrome that are starting to yield insights into this condition.
Similar articles
-
MeCP2 and other methyl-CpG binding proteins.Ment Retard Dev Disabil Res Rev. 2002;8(2):87-93. doi: 10.1002/mrdd.10021. Ment Retard Dev Disabil Res Rev. 2002. PMID: 12112733 Review.
-
MeCP2 in neurons: closing in on the causes of Rett syndrome.Hum Mol Genet. 2005 Apr 15;14 Spec No 1:R19-26. doi: 10.1093/hmg/ddi102. Hum Mol Genet. 2005. PMID: 15809268 Review.
-
Rett syndrome model suggests MECP2 gives neurons the quiet they need to think.Nat Neurosci. 2001 Apr;4(4):342-3. doi: 10.1038/85970. Nat Neurosci. 2001. PMID: 11276217 No abstract available.
-
Expression pattern of the Rett syndrome gene MeCP2 in primate prefrontal cortex.Neurobiol Dis. 2001 Oct;8(5):784-91. doi: 10.1006/nbdi.2001.0420. Neurobiol Dis. 2001. PMID: 11592848
-
Associations between MeCP2 mutations, X-chromosome inactivation, and phenotype.Ment Retard Dev Disabil Res Rev. 2002;8(2):99-105. doi: 10.1002/mrdd.10026. Ment Retard Dev Disabil Res Rev. 2002. PMID: 12112735 Review.
Cited by
-
Separate respiratory phenotypes in methyl-CpG-binding protein 2 (Mecp2) deficient mice.Pediatr Res. 2006 Apr;59(4 Pt 1):513-8. doi: 10.1203/01.pdr.0000203157.31924.4a. Pediatr Res. 2006. PMID: 16549521 Free PMC article.
-
Methyl CpG-binding proteins induce large-scale chromatin reorganization during terminal differentiation.J Cell Biol. 2005 Jun 6;169(5):733-43. doi: 10.1083/jcb.200502062. J Cell Biol. 2005. PMID: 15939760 Free PMC article.
-
Reversal of neurological defects in a mouse model of Rett syndrome.Science. 2007 Feb 23;315(5815):1143-7. doi: 10.1126/science.1138389. Epub 2007 Feb 8. Science. 2007. PMID: 17289941 Free PMC article.
-
Methylation as a key regulator of Tau aggregation and neuronal health in Alzheimer's disease.Cell Commun Signal. 2021 May 7;19(1):51. doi: 10.1186/s12964-021-00732-z. Cell Commun Signal. 2021. PMID: 33962636 Free PMC article. Review.
-
Rotenone Stereospecifically Increases (S)-2-Hydroxyglutarate in SH-SY5Y Neuronal Cells.Chem Res Toxicol. 2015 May 18;28(5):948-54. doi: 10.1021/tx500535c. Epub 2015 Apr 8. Chem Res Toxicol. 2015. PMID: 25800467 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases
