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Comparative Study
. 2003 Nov;44(3):138-47.
doi: 10.1007/s00294-003-0432-1. Epub 2003 Aug 20.

Cryptosporidium parvum Cpn60 targets a relict organelle

Christina E Riordan  1 , Jeffrey G Ault, Susan G Langreth, Janet S Keithly
Affiliations
Comparative Study

Cryptosporidium parvum Cpn60 targets a relict organelle

Christina E Riordan et al. Curr Genet. 2003 Nov.

Abstract

Chaperonin 60 (Cpn60) is a well-established marker protein for eukaryotic mitochondria and plastids. In order to determine whether the small double-membrane-bounded organelle posterior to the nucleus in the apicomplexan Cryptosporidium parvum is a mitochondrion, the Cpn60 gene of C. parvum sporozoites ( CpCpn60) was analyzed and antibodies were generated for localization of the peptide. Sequence and phylogenetic analyses indicated that CpCpn60 is a mitochondrial isotype and that antibodies against it localize to the rough endoplasmic reticulum-enveloped remnant organelle of C. parvum sporozoites. These data show this organelle is of mitochondrial origin.

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