Squamous cell carcinoma of the big toe successfully treated by intra-arterial infusion with methotrexate

Abstract

Background: For preservation of integrity of appearance and function in a 57-year-old male with a squamous cell carcinoma of his left big toe who had refused amputation, intra-arterial infusion with methotrexate was used.

Objective: To evaluate the effectiveness of arterial infusion with methotrexate in this uncommon big toe cancer.

Methods: Left external iliac arterial catheterization and infusion with methotrexate (50 mg) were used every 24 hours plus simultaneous intramuscular injection of 6 mg of leucovorin every 6 hours for 8 days.

Results: At 7 years and 3 months after therapy, the patient was in sustained complete remission with a functionally normal left foot.

Conclusion: This case study suggests that intra-arterial infusion chemotherapy is a simple and effective method for big toe squamous cell carcinoma with the unique advantage of preservation of organ and function. It can be considered as an effective alternative treatment.