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Case Reports
. 2003 Sep;29(9):984-6.
doi: 10.1046/j.1524-4725.2003.29266.x.

Rapidly enlarging growth of the proximal nail fold

Whitney A High  1 , Stephen K Tyring, R Stan Taylor
Affiliations
Case Reports

Rapidly enlarging growth of the proximal nail fold

Whitney A High et al. Dermatol Surg. 2003 Sep.

Abstract

Background: Squamous cell carcinoma (SCC) of the nail unit is a rare but often underappreciated neoplasm. Treatment can be delayed due to confusion with paronychia and verruca. Infection with human papilloma virus (HPV) has been associated with this malignancy.

Objective: To describe the development of a superficially invasive SCC of the proximal nail fold in a patient infected with HIV, to report the association of a previously unrecognized HPV genotype, and to review key etiologic, diagnostic, and therapeutic points as related to SCC of the proximal nail fold.

Results: This is the first report of HPV 26 coinfection in monogamous sexual partners, both of whom are HIV infected and have demonstrated lesions of malignant degeneration consistent with SCC.

Conclusion: SCC must be considered in the differential diagnosis of nail fold neoplasm. An immunocompromised condition such as HIV/AIDS may predispose to malignant degeneration of lesions caused by infection with HPV.

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