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Review
. 2003 Aug;7(4):308-14.
doi: 10.1186/cc2164. Epub 2003 Apr 4.

Science review: Genetic variability in the systemic inflammatory response

Grant W Waterer  1 , Richard G Wunderink
Affiliations
Review

Science review: Genetic variability in the systemic inflammatory response

Grant W Waterer et al. Crit Care. 2003 Aug.

Abstract

The present review discusses recent studies that have identified genetic differences in inflammatory proteins associated with different phenotypic presentations of systemic inflammation. Basic genetic terminology is defined. Implications of genetic influences on the inflammatory response are discussed. The published associations of specific polymorphisms in antigen recognition pathways, proinflammatory cytokines, anti-inflammatory cytokines, and effector molecules are reviewed. The strongest and most consistent associations thus far have been with the tumor necrosis factor, lymphotoxin-alpha, and IL-1 receptor antagonist polymorphisms. However, large, phenotypically detailed studies are required to address all of the other potential polymorphisms in inflammatory molecule genes and their interactions.

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Figures

Figure 1
Figure 1
Area in short arm of chromosome 6, demonstrating the close proximity of many genes that are involved in inflammatory responses within the human leukocyte antigen (HLA) locus.
See this image and copyright information in PMC

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