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Review
. 2003 Aug;7(4):308-14.
doi: 10.1186/cc2164. Epub 2003 Apr 4.

Science review: Genetic variability in the systemic inflammatory response

Grant W Waterer  1 , Richard G Wunderink
Affiliations
Review

Science review: Genetic variability in the systemic inflammatory response

Grant W Waterer et al. Crit Care. 2003 Aug.

Abstract

The present review discusses recent studies that have identified genetic differences in inflammatory proteins associated with different phenotypic presentations of systemic inflammation. Basic genetic terminology is defined. Implications of genetic influences on the inflammatory response are discussed. The published associations of specific polymorphisms in antigen recognition pathways, proinflammatory cytokines, anti-inflammatory cytokines, and effector molecules are reviewed. The strongest and most consistent associations thus far have been with the tumor necrosis factor, lymphotoxin-alpha, and IL-1 receptor antagonist polymorphisms. However, large, phenotypically detailed studies are required to address all of the other potential polymorphisms in inflammatory molecule genes and their interactions.

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Figures

Figure 1
Figure 1
Area in short arm of chromosome 6, demonstrating the close proximity of many genes that are involved in inflammatory responses within the human leukocyte antigen (HLA) locus.
See this image and copyright information in PMC

References

    1. Sorensen TI, Nielsen GG, Andersen PK, Teasdale TW. Genetic and environmental influences on premature death in adult adoptees. N Engl J Med. 1988;318:727–732. - PubMed
    1. Li M, Pritchard PH. Characterization of the effects of mutations in the putative branchpoint sequence of intron 4 on the splicing within the human lecithin:cholesterol acyltransferase gene. J Biol Chem. 2000;275:18079–18084. doi: 10.1074/jbc.M910197199. - DOI - PubMed
    1. Artiga MJ, Saez AI, Romero C, Sanchez-Beato M, Mateo MS, Navas C, Mollejo M, Piris MA. A short mutational hot spot in the first intron of BCL-6 is associated with increased BCL-6 expression and with longer overall survival in large B-cell lymphomas. Am J Pathol. 2002;160:1371–1380. - PMC - PubMed
    1. Bone RC. Sir Isaac Newton, sepsis, SIRS, and CARS. Crit Care Med. 1996;24:1125–1128. doi: 10.1097/00003246-199607000-00010. - DOI - PubMed
    1. Peters M, Petros A, Dixon G, Inwald D, Klein N. Acquired immunoparalysis in paediatric intensive care: prospective observational study. BMJ. 1999;319:609–610. - PMC - PubMed

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