Mechanisms of local, low-dose UVB-induced immunosuppression in contact hypersensitivity

Abstract

Preirradiation of contact sensitizing sites to low-dose ultraviolet B (UVB) renders animals unresponsive to challenge reaction. This unresponsiveness is known as local, low-dose UVB-induced immunosuppression. Although researchers in this area have developed theories, the exact mechanisms of UVB-induced immunosuppression are still a matter of controversy. This article reviewed various scientific data on UVB-induced immunosuppression, categorizing them into individual sequential steps in the whole cascade.